The safety and efficacy of Symmetrel in newborn infants and infants below the age of 1 year have not been established. When SYMMETREL amantadine hydrochloride and levodopa are initiated concurrently, the patient can exhibit rapid benefits. SYMMETREL amantadine hydrochloride should be held constant at 100 mg daily or twice daily while the daily dose of levodopa is gradually increased to optimal benefit. Interferon can make you more likely to get infections or may worsen any current infections.
Influenza A prophylaxis: Refer to "Influenza A treatment" dosing. Note: Continue prophylaxis throughout the peak influenza activity in the community or throughout the entire influenza season in patients who cannot be vaccinated. Although amantadine has not been shown to possess direct anticholinergic activity in animal studies, clinically, it exhibits anticholinergic-like side effects such as dry mouth, urinary retention, and constipation. What is the most important information I should know about amantadine Symmetrel? Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy.
Fatalities reported following overdosage. 1 2 6 Overdosage has resulted in cardiac arrhythmia, tachycardia, hypertension respiratory, renal, or CNS toxicity; may be related to anticholinergic effects of the drug. The initial dose of Amantadine Hydrochloride Tablets is 100 mg daily for patients with serious associated medical illnesses or who are receiving high doses of other antiparkinson drugs. After one to several weeks at 100 mg once daily, the dose may be increased to 100 mg twice daily, if necessary. Occasionally, patients whose responses are not optimal with Amantadine Hydrochloride Tablets at 200 mg daily may benefit from an increase up to 400 mg daily in divided doses. However, such patients should be supervised closely by their physicians.
Care should be exercised when administering adrenergic agents, such as isoproterenol, to patients with an amantadine hydrochloride overdose, since the dopaminergic activity of amantadine hydrochloride has been reported to induce malignant arrhythmias. Amantadine probably does not inhibit MAO enzyme. Moreover, the mechanism of its antiparkinsonian effect is poorly understood. The usual dose of amantadine hydrochloride is 100 mg twice a day when used alone. Amantadine hydrochloride has an onset of action usually within 48 hours.
In Parkinson's disease, the effects of the medication may not be noticed for several weeks. Do not suddenly stop taking the medication because symptoms or side effects may worsen. Your doctor may want to reduce your dose gradually. This medication may not work as well after it has been taken for several months. Tell your doctor if this medication stops working well. The adult daily dosage of amantadine hydrochloride is 200 mg: four teaspoonfuls of oral solution as a single daily dose. The daily dosage may be split into two teaspoonfuls of oral solution twice a day. If central nervous system effects develop in once-a-day dosage, a split dosage schedule may reduce such complaints. SYMMETREL amantadine hydrochloride is indicated in the treatment of drug-induced extrapyramidal reactions. Although anticholinergic-type side effects have been noted with SYMMETREL amantadine hydrochloride when used in patients with drug-induced extrapyramidal reactions, there is a lower of these side effects than that observed with the anticholinergic antiparkinson drugs. Practice GLP and according to current recommended methodology. Note: Patients with a serious concomitant illness or those receiving high doses of other antiparkinson drugs should be started at 100 mg once daily; may increase to 100 mg twice daily, if needed, after one to several weeks. Elderly: Use with caution in the elderly; may be more susceptible to CNS effects using 2 divided daily doses may minimize this effect. These patients may require dosage reductions. Patients with a history of epilepsy or other “seizures” should be observed closely for possible increased seizure activity. Symptomatic treatment of parkinsonian syndrome including postencephalitic, idiopathic, arteriosclerotic types and for the relief of parkinsonian signs and symptoms of carbon monoxide poisoning. 1 2 6 Less effective than levodopa. The total daily dose is 200 mg given as one capsule of 100 mg twice a day. The 100 mg daily dose has not been studied in this pediatric population. Therefore, there are no data which demonstrate that this dose is as effective as or is safer than the 200 mg daily dose in this patient population. Use with caution in patients with recurrent eczematoid dermatitis. Continued What Are the Symptoms?
Amantadine hydrochloride has pharmacological actions as both an anti-Parkinson and an antiviral drug. Parkinson disease developed syndrome of inappropriate antidiuretic hormone secretion nine days after starting amantadine and entacapone. The patient did not recover following discontinuation of entacapone. Five days after entacapone was stopped, amantadine was discontinued. The patient gradually improved following amantadine discontinuation. Voeller GW. German study: role of Symmetrel eg; in drug treatment. In: Birdwood GFB et al, eds. Parkinson's disease. A new approach to treatment. Academic Press. To relieve dry mouth, suck on sugarless hard candy or ice chips, chew sugarless gum, drink water, or use a saliva substitute. Pearlman JT, Kadish AH, Ramseyer JC "Vision loss associated with amantadine hydrochloride use. The dose of anticholinergic drugs or of Symmetrel should be reduced if atropine-like effects appear when these drugs are used concurrently. Abrupt discontinuation may also precipitate delirium, agitation, delusions, hallucinations, paranoid reaction, stupor, anxiety, depression and slurred speech. Centers for Disease Control and Prevention CDC. Update: influenza activity--United States, September 28, 2008-April 4, 2009, and composition of the 2009-10 influenza vaccine. MMWR Morb Mortal Wkly Rep. coumadin
Importance of not getting up suddenly from a sitting or lying position; notify clinician if dizziness or lightheadedness occurs. The Cochrane database of systematic reviews. 11: CD002745. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Long-term in vivo animal studies designed to evaluate the carcinogenic potential of Symmetrel have not been performed. In several in vitro assays for gene mutation, Symmetrel did not increase the number of spontaneously observed mutations in four strains of Salmonella typhimurium Ames Test or in a mammalian cell line Chinese Hamster Ovary cells when incubations were performed either with or without a liver metabolic activation extract. Wilson TW, Rajput AH. Amantadine-dyazide interaction. Van Ketel WG, Goedhart-Van Dijk B. Fotosensitization by amantadine Symmetrel . Dermatologica. Have you had any other symptoms besides double vision? Agents with anticholinergic properties may potentiate the anticholinergic-like side effects of amantadine. The blood electrolytes, urine pH and urinary output should be monitored. If there is no record of recent voiding, catheterization should be done. Influenza A: Appropriate use: Consult current guidelines. Due to increased resistance, the ACIP has recommended that rimantadine and amantadine no longer be used for the treatment or prophylaxis of influenza A in the United States until susceptibility has been re-established CDC 2011. Amantadine hydrochloride should be used during pregnancy only if the potential benefit justifies the potential risk to the embryo or fetus. Manufactured for: Endo Pharmaceuticals Inc. See Renal Impairment under Dosage and Administration. Amantadine-resistant influenza A viruses also are resistant to rimantadine and vice versa. Hong Kong infection. Lancet. Educate patient about signs of a significant reaction eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat. Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions. can i purchase eprex pills eprex
Surgery almost always fixes them. Double vision that's new or unexplained needs medical care right away. With so many potential causes, it's important to discover the reason without delay. Drink several glasses of water each day. Sacral nerve stimulator. A surgeon implants a device that stimulates the pelvic nerves. Watson Pharma Private Ltd. Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed. Alves Galvão, MG; Rocha Crispino Santos, MA; Alves da Cunha, AJ 21 November 2014. "Amantadine and rimantadine for influenza A in children and the elderly. Dosage can be increased to 400 mg daily in divided doses in patients with parkinsonian syndrome. Known hypersensitivity to amantadine or any ingredient in the formulation. Amantadine Hydrochloride Tablets are also indicated in the treatment of uncomplicated respiratory tract illness caused by influenza A virus strains especially when administered early in the course of illness. There are no well-controlled clinical studies demonstrating that treatment with Amantadine Hydrochloride Tablets will avoid the development of influenza A virus pneumonitis or other complications in high risk patients. There is no clinical evidence indicating that Amantadine Hydrochloride Tablets are effective in the prophylaxis or treatment of viral respiratory tract illnesses other than those caused by influenza A virus strains.
Noveske FG "Breakthrough panic after amantadine treatment in a parkinson's disease patient. The adverse reactions reported most frequently at the recommended dose of amantadine 5-10% are: nausea, dizziness lightheadedness and insomnia. EEG changes, and tremor. Muzi F, Orlando G, Ielpo B, et al. "Amantadine monotherapy is ineffective in the treatment of hepatitis C virus recurrence in the post-liver transplantation setting. Nora JJ et al. Cardiovascular maldevelopment associated with maternal exposure to amantadine. Lancet. Since the excretion rate of SYMMETREL amantadine hydrochloride increases rapidly when the urine is acidic, the administration of urine acidifying drugs may increase the elimination of the drug from the body. The usual dose of SYMMETREL amantadine hydrochloride is 100 mg twice a day when used alone. SYMMETREL amantadine hydrochloride has an onset of action usually within 48 hours. Allergic reactions, including anaphylactic reaction, 1 2 6 rash, 1 2 6 eczematoid dermatitis, 1 2 6 photosensitization, 86 pruritus, 1 2 6 and diaphoresis, 1 2 6 reported rarely. The adult daily dosage of Amantadine Hydrochloride Tablets is 200 mg; two 100 mg tablets as a single daily dose. The daily dosage may be split into one tablet of 100 mg twice a day. If central nervous system effects develop in once-a-day dosage, a split dosage schedule may reduce such complaints. Some patients who do not respond to anticholinergic antiparkinson drugs may respond to amantadine hydrochloride. When amantadine hydrochloride or anticholinergic antiparkinson drugs are each used with marginal benefit, concomitant use may produce additional benefit. The clear window into your eye. Its main job is to focus light. If your double vision goes away when you cover one eye, you might have cornea damage in the uncovered eye. However, it has not been demonstrated that a 100 mg daily dose is as effective as a 200 mg daily dose for prophylaxis, nor has the 100 mg daily dose been studied in the treatment of acute influenza illness. In recent clinical trials, the incidence of central nervous system CNS side effects associated with the 100 mg daily dose was at or near the level of placebo. The 100 mg dose is recommended for persons who have demonstrated intolerance to 200 mg of amantadine hydrochloride tablets daily because of CNS or other toxicities. cheap domperidone fast shipping domperidone
Morton Grove, IL; 2011 Sep. Amantadine Hydrochloride Capsules, USP are also indicated in the treatment of uncomplicated respiratory tract illness caused by influenza A virus strains especially when administered early in the course of illness. There are no well-controlled clinical studies demonstrating that treatment with Amantadine Hydrochloride Capsules, USP will avoid the development of influenza A virus pneumonitis or other complications in high risk patients. Older adults may be more sensitive to the side effects of this drug, especially dizziness, drowsiness, heatstroke, memory problems, difficulty urinating, and constipation. Dizziness and drowsiness can increase the risk of falling. NMS is an uncommon but life-threatening syndrome characterized by fever or hyperthermia; neurologic findings including muscle rigidity, involuntary movements, altered consciousness; mental status changes; other disturbances such as autonomic dysfunction, tachycardia, tachypnea, hyper - or hypotension; laboratory findings such as creatine phosphokinase elevation, leukocytosis, myoglobinuria, and increased serum myoglobin. Parkinson's disease: Appropriate use: When treating Parkinson disease, do not discontinue abruptly. In many patients, the therapeutic benefits of amantadine are limited to a few months. Committee on Infectious Disease. What is the prognosis for patients who get the flu? Amantadine hydrochloride tablets are indicated in the treatment of idiopathic Parkinson's disease Paralysis Agitans postencephalitic parkinsonism, and symptomatic parkinsonism which may follow injury to the nervous system by carbon monoxide intoxication. It is indicated in those elderly patients believed to develop parkinsonism in association with cerebral arteriosclerosis. Amantadine hydrochloride tablets are also indicated in the treatment of uncomplicated respiratory tract illness caused by influenza A virus strains especially when administered early in the course of illness. There are no well-controlled clinical studies demonstrating that treatment with amantadine hydrochloride tablets will avoid the development of influenza A virus pneumonitis or other complications in high risk patients. There is no clinical evidence indicating that amantadine hydrochloride tablets are effective in the prophylaxis or treatment of viral respiratory tract illnesses other than those caused by influenza A virus strains. Gaudry SE, Sitar DS, Smyth DD et al. Gender and age as factors in the inhibition of renal clearance of amantadine by quinine and quinidine. Clin Pharmacol Ther. How effective is the flu vaccine? When should someone get the flu shot? The blood electrolytes, and output should be monitored. Sphincter surgery. A surgeon can stitch the anal muscles more tightly together sphincteroplasty. Or the surgeon takes muscle from the pelvis or buttock to support the weak anal muscles muscle transposition. These surgeries can cure many people with bowel incontinence that's due to a tear of the anal sphincter muscles. kenalog price down
Nausea, 1 2 6 dizziness lightheadedness 1 2 6 49 insomnia. Advise patients with parkinsonian syndrome to gradually increase physical activity as symptoms improve. Patients initially deriving benefit from Amantadine Hydrochloride Tablets not uncommonly experience a fall-off of effectiveness after a few months. Benefit may be regained by increasing the dose to 300 mg daily. Alternatively, temporary discontinuation of Amantadine Hydrochloride Tablets for several weeks, followed by reinitiation of the drug, may result in regaining benefit in some patients. A decision to use other antiparkinson drugs may be necessary. Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. Recommended treatments vary according to the cause of bowel incontinence. Often, more than one treatment method may be required to control symptoms.
Half-life prolonged in healthy geriatric adults. Occasionally, patients whose responses are not optimal with SYMMETREL amantadine hydrochloride at 200 mg daily may benefit from an increase up to 400 mg daily in divided doses. However, such patients should be supervised closely by their physicians. Patients initially deriving benefit from amantadine hydrochloride not uncommonly experience a fall-off of effectiveness after a few months. Benefit may be regained by increasing the dose to 300 mg daily. Alternatively, temporary discontinuation of amantadine hydrochloride for several weeks followed by reinitiation of the drug, may result in regaining benefit in some patients. A decision to use other antiparkinson drugs may be necessary. However, it has not been demonstrated that a 100 mg daily dose is as effective as a 200 mg daily dose for prophylaxis, nor has the 100 mg daily dose been studied in the treatment of acute influenza illness. In recent clinical trials, the incidence of central nervous system CNS side effects associated with the 100 mg daily dose was at or near the level of placebo. The 100 mg dose is recommended for persons who have demonstrated intolerance to 200 mg of Amantadine Hydrochloride Tablets daily because of CNS or other toxicities. Antiviral drugs for influenza. Occasionally, patients whose responses are not optimal with Symmetrel at 200 mg daily may benefit from an increase up to 400 mg daily in divided doses. However, such patients should be supervised closely by their physicians. The adverse reactions reported most frequently at the recommended dose of Symmetrel 5-10% are: nausea, dizziness lightheadedness and insomnia. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. order acarbose online legally
Influenza B strains possess a structurally distinct M2 channels with channel-facing side chains that fully obstruct the channel vis-a-vis binding of adamantine-class channel inhibitors, while still allowing proton flow and channel function to occur; this constriction in the channels is responsible for the ineffectiveness of this drug and rimantadine towards all circulating Influenza B strains. If you are currently using the medication listed above, tell your doctor or pharmacist before starting trihexyphenidyl. Soung LS, Ing TS, Daugirdas JT et al. Amantadine hydrochloride pharmacokinetics in hemodialysis patients. Ann Intern Med. Some patients who do not respond to anticholinergic antiparkinson drugs may respond to Amantadine Hydrochloride Tablets. When Amantadine Hydrochloride Tablets or anticholinergic antiparkinson drugs are each used with marginal benefit, concomitant use may produce additional benefit. Symmetrel. Although it is not proven that the medications caused these events, these urges were reported to have stopped in some cases when the dose was reduced or the medication was stopped. Prescribers should ask patients about the development of new or increased gambling urges, sexual urges or other urges while being treated with Symmetrel. Patients should inform their physician if they experience new or increased gambling urges, increased sexual urges or other intense urges while taking Symmetrel. Physicians should consider dose reduction or stopping the medication if a patient develops such urges while taking Symmetrel. Please refer to the for information on shortages of one or more of these preparations. Resistance to the drug class is a consequence of mutations to the pore-lining residues of the channel, leading to the inability of the sterically bulky adamantane ring that both share in entering in their usual way, into the channel. H3N2 viruses isolated during the epidemics of 1988 to 1989 and 1989 to 1990. Antimicrob Agents Chemother. Take this medication regularly in order to get the most benefit from it. To help you remember, take it at the same times each day. Consider viral surveillance data available from local and state health departments and the CDC when selecting an antiviral for prophylaxis of influenza. 112 137 144 The most appropriate antiviral for prevention of influenza is selected based on information regarding the likelihood that the influenza strain is susceptible and the known adverse effects of the drug. 137 144 Strains of circulating influenza viruses and the antiviral susceptibility of these strains constantly evolve. adli.info revia
Epidemiological studies have shown that patients with Parkinson's disease have a higher risk 2-to approximately 6-fold higher of developing melanoma than the general population. Whether the increased risk observed was due to Parkinson's disease or other factors, such as drugs used to treat Parkinson's disease, is unclear. Only minimally removed by hemodialysis. Liquid forms of this product may contain alcohol. Caution is advised if you have diabetes, alcohol dependence, or liver disease. Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose. Serious bacterial infections may present with influenza-like symptoms or may coexist with or occur as complications of influenza. 1 2 6 No evidence that amantadine prevents such complications.
Acute toxicity may be attributable to the anticholinergic effects of amantadine. Drug overdose has resulted in cardiac, respiratory, renal or central nervous system toxicity. Cardiac dysfunction includes arrhythmia, tachycardia and hypertension. Nerve tests. These tests measure the responsiveness of the nerves controlling the sphincter muscles. They can detect that can cause bowel incontinence. To understand what can go wrong, it helps know the parts of your eye and how they work together. Take this medication at least 1 hour before antacids containing magnesium, aluminum, or calcium. Allow at least 1-2 hours between doses of trihexyphenidyl and certain drugs for diarrhea adsorbent antidiarrheals such as kaolin, pectin, attapulgite. Take this medication at least 2 hours after ketoconazole. Antacids and some drugs for diarrhea may prevent the full absorption of trihexyphenidyl, and this product may prevent the complete absorption of ketoconazole when these products are taken together. Risk of CNS effects and blurred vision; use caution when alertness and motor coordination is needed. Crosby, Niall J; Deane, Katherine; Clarke, Carl E 2003. Clarke, Carl E, ed. "Amantadine in Parkinson's disease". Cochrane Database of Systematic Reviews. Keller EB. Amantadine intoxication reversed by physostigmine. N Engl J Med. When used for parkinsonian syndrome, onset of action usually within 48 hours. This drug can cause decreased sweating, which could cause a severe rise in your body temperature hyperthermia. Coadministration of thioridazine has been reported to worsen the tremor in elderly patients with Parkinson's disease, however, it is not known if other phenothiazines produce a similar response. Smordintsev AA et al. Evaluation of amantadine in artificially induced A 2 and B influenza. JAMA. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your or local waste disposal company. Cover one eye, then switch. Does the problem go away when either eye is covered? buy cheapest carbimazole shop australia
Some of the side effects that can occur with amantadine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. Amantadine hydrochloride oral solution USP is indicated for the prophylaxis and treatment of signs and symptoms of infection caused by various strains of influenza A virus. Amantadine hydrochloride oral solution USP is also indicated in the treatment of parkinsonism and drug-induced extrapyramidal reactions. The concurrent use of Symmetrel with live attenuated influenza vaccine LAIV intranasal has not been evaluated. However, because of the potential for interference between these products, LAIV should not be administered within 2 weeks before or 48 hours after administration of Symmetrel, unless medically indicated. The concern about possible interference arises from the potential for antiviral drugs to inhibit replication of live vaccine virus. Trivalent inactivated influenza vaccine can be administered at any time relative to use of Symmetrel. When amantadine hydrochloride is added to optimal well-tolerated doses of levodopa, additional benefit may result, including smoothing out the fluctuations in improvement which sometimes occur in patients on levodopa alone. Patients who require a reduction in their usual dose of levodopa because of development of side effects may possibly regain lost benefit with the addition of amantadine hydrochloride. Alonso Navarro H, Sanz-Aiz A, Izquierdo L, Jimenez Jimenez FJ "Syndrome of Inappropriate Antidiuretic Hormone Secretion Possibly Associated With Amantadine Therapy in Parkinson Disease. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Congestive heart failure with severe lower limb edema was diagnosed in one patient receiving amantadine, but resolved following drug discontinuation. A positive correlation with amantadine therapy could not be established, although no other cause for this patient's heart failure was found. Where can I get more information? Banner Pharmacaps Inc. Amantadine hydrochloride capsule, liquid filled prescribing information. High Point, NC; 2012 Jul. Do not receive a "live" nasal flu vaccine FluMist while using amantadine, and for at least 48 hours after you stop taking amantadine. The vaccine may not work as well during this time, and may not fully protect you from disease. People with Parkinson's disease may have an increased risk for developing skin cancer melanoma. If you are taking this drug to treat Parkinson's disease, tell your doctor promptly if you notice a change in the appearance or size of moles or other unusual skin changes. Ask your doctor if you should have regular skin exams. gemfibrozil
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Dolin R, Reichman RC, Madore HP, et al "A controlled trial of amantadine and rimantadine in the prophylaxis of influenza A infection. Patients with a history of epilepsy or other seizure disorders should be observed closely for possible increased seizure activity. Treatment of influenza A virus illness should be started as soon as possible, preferably within 24 to 48 hours after of signs and symptoms, and should be continued for 24 to 48 hours after the disappearance of signs and symptoms. where to estreva sukhumvit
There appears to be a relationship between plasma amantadine concentrations and toxicity. As concentration increases, toxicity seems to be more prevalent, however, absolute values of amantadine concentrations associated with adverse effects have not been fully defined. How should I take amantadine Symmetrel? The opinions expressed in WebMD Communities are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. Communities are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions.
To increase comfort, remove this medication from the refrigerator and let it warm to room temperature for about 30 minutes before injecting. Do not warm up this medication in any other way such as heating in the microwave or placing in hot water. Suicide attempts, some of which have been fatal, have been reported in patients treated with Symmetrel, many of whom received short courses for influenza treatment or prophylaxis. The incidence of suicide attempts is not known and the pathophysiologic mechanism is not understood. Suicide attempts and suicidal ideation have been reported in patients with and without prior history of psychiatric illness. Symmetrel can exacerbate mental problems in patients with a history of psychiatric disorders or substance abuse. Patients who attempt suicide may exhibit abnormal mental states which include disorientation, confusion, depression, personality changes, agitation, aggressive behavior, hallucinations, paranoia, other psychotic reactions, and somnolence or insomnia. Because of the possibility of serious adverse effects, caution should be observed when prescribing Symmetrel to patients being treated with drugs having CNS effects, or for whom the potential risks outweigh the benefit of treatment.
The lowest reported dose was 1 gram. Because some patients have attempted suicide by overdosing with amantadine, prescriptions should be written for the smallest quantity consistent with good patient management. Anon. Amantadine and rimantadine. In: Kucers A, Crowe SM, Grayson ML et al, eds. The use of antibiotics: a clinical review of antibacterial, antifungal and antiviral drugs. Amantadine Hydrochloride Capsules, USP should be continued daily for at least 10 days following a known exposure. If Amantadine Hydrochloride Capsules, USP are used chemoprophylactically in conjunction with inactivated influenza A virus vaccine until protective antibody responses develop, then it should be administered for 2 to 4 weeks after the vaccine has been given. When inactivated influenza A virus vaccine is unavailable or contraindicated, Amantadine Hydrochloride Capsules, USP should be administered for the duration of known influenza A in the community because of repeated and unknown exposure.